|
T2029 |
Bohemine
|
|
ERK
,
CDK
|
|
Bohemine is a cyclin-dependent kinase inhibitor. |
|
T7426 |
ALSTERPAULLONE
|
|
Apoptosis
,
GSK-3
,
CDK
|
|
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec |
|
T1901 |
(E/Z)-TG003
|
TG003 |
BCL
,
CDK
|
|
(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor. |
|
T21503 |
(E/Z)-Zotiraciclib
|
(E/Z)-TG02,(E/Z)-SB1317 |
FLT
,
JAK
,
CDK
|
|
(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively. |
|
T2378 |
RGB-286638 free base
|
|
GSK-3
,
MEK
,
JAK
,
CDK
|
|
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a... |
|
T2059 |
Purvalanol A
|
NG-60 |
Apoptosis
,
CDK
,
Autophagy
|
|
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. |
|
T2095 |
Seliciclib
|
Roscovitine,R-roscovitine,CYC202 |
CDK
|
|
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM). |
|
T5200 |
Indirubin-3'-monoxime
|
Indirubin-3'-oxime |
GSK-3
,
Lipoxygenase
,
CDK
|
|
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). |
|
T8796 |
CAN508
|
|
CDK
|
|
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50... |
|
T7167 |
Purvalanol B
|
NG 95 |
CDK
,
Parasite
|
|
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) |
|
T22260 |
Aminopurvalanol A
|
|
CDK
|
|
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... |
|
T2679 |
BMS-265246
|
BMS265246 |
CDK
|
|
BMS-265246 is a potent and selective CDK1/2 inhibitor. |
|
T4321 |
Indisulam
|
E 7070 |
CDK
,
Carbonic Anhydrase
|
|
Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in th... |
|
T2356 |
Ro-3306
|
|
Apoptosis
,
ERK
,
SGK
,
PKA
,
CDK
,
PKC
|
|
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases. |
|
T14943 |
CGP60474
|
|
VEGFR
,
CDK
,
PKC
|
|
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. |
|
T2247 |
KenPaullone
|
9-Bromopaullone,NSC-664704 |
GSK-3
,
CDK
|
|
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp... |
|
T6312 |
R547
|
Ro 4584820 |
Apoptosis
,
GSK-3
,
PKA
,
CDK
|
|
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. |
|
T35610 |
2,5-dimethyl Celecoxib
|
|
Apoptosis
,
Wnt/beta-catenin
,
Prostaglandin Receptor
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
|
T11653 |
Indirubin-5-sulfonate
|
|
Others
|
|
Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cycli... |
|
T22590 |
AT7519 TFA
|
AT7519 trifluoroacetate |
Others
|
|
AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35). |
|
T73196 |
RGB-286638
|
|
|
|
RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM... |
|
T21377 |
Aloisine A
|
|
|
|
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GS... |
|
T61890 |
(E/Z)-BIO-acetoxime
|
|
|
|
(E/Z) - BIO-acetoxime is effective and selective GSK-3 α/β Inhibitors. For GSK-3 α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, IC50 are 10nM, 2.4 μM, 4.3 μ M, 63 μ M, respectively。 |
|
T40289 |
CDK12-IN-6
|
CDK12-IN-6 |
|
|
CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not e... |
|
T40288 |
CDK12-IN-4
|
CDK12-IN-4 |
|
|
CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or C... |
|
T40290 |
CDK12-IN-5
|
CDK12-IN-5 |
|
|
CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50... |
|
T37065 |
6-Chloro-2-fluoropurine
|
|
|
|
6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the ... |
|
T35525 |
PI3-Kinase α Inhibitor 2
|
PI3-Kinase α Inhibitor 2 |
|
|
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed ... |
|
T62235 |
CDK-IN-9
|
|
|
|
CDK-IN-9 (compound 24) is a potent inhibitor of CDK. CDK-IN-9 is also a molecular gel that induces interaction between CDK12 and DDB1 and is able to act on CDK2/E (IC50: 4 nM). CDK-IN-9 can be used to dephosphorylate ret... |
